KDM5C Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 14426-1-AP

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Freight/Packing

Con: 25 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
HeLa cells

Positive IF detected in:
HeLa cells

Recommended dilution:
WB : 1:500-1:1000
IF : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
lysine (K)-specific demethylase 5C

Calculated molecular weight:
176 kDa

Observed molecular weight:
171-180 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
KDM5C

Synonyms
DXS1272E, Histone demethylase JARID1C, JARID1C, KDM5C, lysine (K) demethylase 5C, Lysine specific demethylase 5C, MRXJ, MRXSJ, Protein SmcX, Protein Xe169, SMCX, XE169
Background

KDM5C belongs to the ARID protein family that harbors conserved DNA-binding motifs and acts as a histone H3 lysine 4 demethylase, suggesting a potential role in epigenetic regulation during development, cell growth and differentiation [PMID:21575681]KDM5C protein is homologous to three other proteins of the human JARID1 family (JARID1A, JARID1B and JARID1C). This family shares several evolutionarily conserved domains, including the catalytic JmjC domain, JmjN domain, Arid/Bright domain, C5HC2 zinc-finger domain and two plant homeodomains (PHD), a motif that binds methyl-lysine residues [PMID:17320160,17320161].


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