KEAP1 Antibody 14 Publications

Mouse Monoclonal| Catalog number: 60027-1-Ig |CloneNo.: 4G10H9

Featured Product KD/KO validated

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Freight/Packing

Con: 75 μg/150 μl

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Species specificity:
human, rat, mouse

Positive WB detected in:
HeLa cells

Positive IHC detected in:
human endometrial cancer tissue, human kidney tissue, human pancreas cancer tissue, human skeletal muscle tissue

Recommended dilution:
WB : 1:500-1:1000
IHC : 1:50-1:500

Product Information


Source:
Mouse

Purification method:
Caprylic acid/ammonium sulfate precipitation

Isotype:
IgA

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
kelch-like ECH-associated protein 1

Calculated molecular weight:
624aa,70 kDa

Observed molecular weight:
70 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
KEAP1

Synonyms
Cytosolic inhibitor of Nrf2, INrf2, KEAP1, Kelch like protein 19, KIAA0132, KLHL19
Background

KEAP1, also named as INRF2, KIAA0132 and KLHL19, is part of a multiprotein complex that contains the CUL3-ROC1 ubiquitin ligase, which can ubiquitinate the N-terminal domain of NRF2. Two molecules of KEAP1 bind to two distinct sites in the N-terminal region of NRF2, the ETGE and DLG sites, which affect the KEAP1-NRF2 interaction and/or its physiological consequences. KEAP1 retains NFE2L2/NRF2 in the cytosol. It functions as substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1. It also retains BPTF in the cytosol. This antibody is a mouse monoclonal antibody raised against residues near the C terminus of human KEAP1.

Read more about this antibody on the blog:http://blog.ptglab.com/index.php/nsclc-research-anti-keap1-antibody-helps-uncover-targets-biomarker-potential/


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