KMO Antibody 2 Publications

Mouse Monoclonal| Catalog number: 60029-1-Ig |CloneNo.: 2D2F2

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Freight/Packing

Con: 93 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
HEK-293 cells, HeLa cells, human heart tissue, mouse brain tissue, SKOV-3 cells

Positive IHC detected in:
human heart tissue, human liver tissue, human ovary tissue, human skin tissue

Positive IF detected in:
C6 cells

Recommended dilution:
WB : 1:500-1:2000
IHC : 1:20-1:200
IF : 1:10-1:100

Product Information


Source:
Mouse

Purification method:
Caprylic acid/ammonium sulfate precipitation

Isotype:
IgG1

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)

Calculated molecular weight:
55.8 kDa

Observed molecular weight:
56 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
KMO

Synonyms
dJ317G22.1, KMO, Kynurenine 3 hydroxylase, Kynurenine 3 monooxygenase
Background

KMO(Kynurenine 3-monooxygenase) is an NADPH-dependent flavin monooxygenase, catalysing the hydroxylation of the L-tryptophan metabolite L-kynurenine to form L-3-hydroxykynurenine. KMO is a membrane protein located on the outer membrane of mitochondria. Tissue distribution studies have revealed that, in rats, highest enzyme activity is found in kidney and liver, with brain having the least activity in comparison to peripheral organs(PMID: 9237672).


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