Kininogen 1 Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 11926-1-AP

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Con: 31 μg/150 μl

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Species specificity:
human

Positive WB detected in:
HeLa cells, A2780 cells, COLO 320 cells, HeLa cells, MCF-7 cells

Positive IHC detected in:
human endometrial cancer tissue, human endometrial cancer tissue, human kidney tissue

Positive IF detected in:
HepG2 cells

Recommended dilution:
WB : 1:500-1:1000
IHC : 1:20-1:200
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
kininogen 1

Calculated molecular weight:
644aa,72 kDa

Observed molecular weight:
60 kDa or 47 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
KNG1

Synonyms
BDK, Fitzgerald factor, HMWK, Ile Ser Bradykinin Bradykinin, Kallidin I Lysyl bradykinin, kininogen 1, KNG, KNG1
Background

Kininogens are inhibitors of thiol proteases. Kininogen 1 plays important role in Kinin-kallikrein system. This gene is translated into High-molecular weight kininogen (HMWK) and low-molecular weight kininogen (LMWK) after alternative splicing. HMWK is produced by the liver together with prekallikrein. It acts mainly as a cofactor on coagulation and inflammation, and has no intrinsic catalytic activity. LMWK is produced locally by numerous tissues, and secreted together with tissue kallikrein. 11926-1-AP was generated against N-terminal 300 aa of HMW kininogen. It can bind both HMW and LMW kiniogen.


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