LATS1 Antibody 1 Publications

Rabbit Polyclonal| Catalog number: 17049-1-AP

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Freight/Packing

Con: 39 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
mouse cerebellum tissue,mouse testis tissue, K-562 cells, SH-SY5Y cells

Positive IHC detected in:
human testis tissue

Recommended dilution:
WB : 1:200-1:1000
IHC : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
LATS, large tumor suppressor, homolog 1 (Drosophila)

Calculated molecular weight:
15 kDa;127 kDa

Observed molecular weight:
140 kDa,120 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
LATS1

Synonyms
h warts, LATS1, WARTS, WARTS protein kinase, wts
Background

LATS1(Large tumor suppressor homolog 1) is also named as WARTS and belongds to the AGC Ser/Thr protein kinase family. The gene encodes a highly conserved (from fly to human) protein kinase that plays a crucial role in the prevention of tumor formation by controlling the progression of mitosis. The expression of both long(170 kDa) and short lats1 isoforms(120 kDa) in vertebrate retinal cells raises the possibility that these lats1 proteins may act as negative key regulators of the cell cycle each of them performing a unique role (PMID:15777619). In mammalian cells, LATS1 was phosphorylated in a cell cycle-dependent manner and complexed with CDC2 in early mitosis (PMID:9988268). LATS1 also can be detected as 120 kDa and 140-150 kDa, and play a key role in the regulation of Hippo pathway (PMID: 27940445).


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