LEPR Antibody 2 Publications

Rabbit Polyclonal| Catalog number: 20966-1-AP

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Freight/Packing

Con: 51 μg/150 μl

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Species specificity:
human, mouse

Positive WB detected in:
mouse heart tissue, mouse heart tissue, PC-3 cells

Positive IP detected in:
mouse heart tissue

Positive IHC detected in:
human prostate hyperplasia tissue, human heart tissue, human prostate hyperplasia tissue

Positive IF detected in:
MCF-7 cells

Positive FC detected in:
HeLa cells

Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:50-1:200
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Immunogen:
Peptide

Full name:
leptin receptor

Calculated molecular weight:
132 kDa

Observed molecular weight:
150 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
LEPR

Synonyms
CD295, DB, HuB219, LEP R, LEPR, leptin receptor, OB R, OB receptor, OBR
Background

The hormone leptin, secreted predominantly from adipose tissue, plays a crucial role in the regulation of numerous neuroendocrine functions, from energy homeostasis to reproduction (PMID: 22249808). Leptin acts through the leptin receptor (LEPR, also known as OB-R), a single-transmembrane-domain receptor of the cytokine receptor family. On ligand binding, LEPR mediates signaling through JAK2/STAT3 (PMID: 9102398). LEPR plays an important role in the regulation of glucose homeostasis via feeding and adiposity. Alternatively spliced transcript variants encoding different isoforms of LEPR have been described. This antibody can recognize long (LEPRb) and short (LEPRa,c,d) isoforms. This antibody detects endogenous LEPR with an apparent molecular weight of 150 kDa, which is larger than the predicted molecular weight, probably due to glycosylation (PMID: 10026237).


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