MMP13 Antibody 24 Publications

Rabbit Polyclonal| Catalog number: 18165-1-AP

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Con: 40 μg/150 μl

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Species specificity:
human, mouse, rat, zebrafish, rabbit

Positive WB detected in:
MDA-MB-453s cells, A2780 cells, MCF-7 cells, zebrafish tissue

Positive IHC detected in:
human breast cancer tissue, human liver cancer tissue

Positive IF detected in:
MCF-7 cells

Recommended dilution:
WB : 1:500-1:1000
IHC : 1:20-1:200
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
matrix metallopeptidase 13 (collagenase 3)

Calculated molecular weight:
471aa,54 kDa

Observed molecular weight:
65-70 kDa, 50-55 kDa, 40 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
MMP13

Synonyms
CLG3, Collagenase 3, Matrix metalloproteinase 13, MMP 13, MMP13
Background

MMP-13(Matrix metalloproteinase-13), also known as collagenase-3, cleaves type I collagen and was previously thought to be the rodent analogue of human interstitial collagenase (MMP-1). MMP-13 is found in hypertrophic and calcifying cartilage of mammalian growth plate. The bands seen with rat MMP-13 are consistent with a 59-kDa latent form and a 43-kDa active form reported for this enzyme ,along with a smaller band at approximately 30 kDa(PMID:10771523). It also can be detected 3 bands that the glycosylated proMMP-13 (70 kDa), unglycosylated proform (55 kDa), and active MMP-13 enzyme (40kDa) by western blot(PMID:18332263).


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