MMP7 Antibody 21 Publications

Rabbit Polyclonal| Catalog number: 10374-2-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 55 μg/150 μl

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Species specificity:
human, mouse

Positive WB detected in:
NIH/3T3 cells, COLO 320 cells, human placenta tissue, mouse lung tissue

Positive IHC detected in:
human pancreas cancer tissue, human pancreas cancer tissue, human stomach tissue

Recommended dilution:
WB : 1:500-1:1000
IHC : 1:50-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
matrix metallopeptidase 7 (matrilysin, uterine)

Calculated molecular weight:
29 kDa

Observed molecular weight:
28-30 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
MMP7

Synonyms
Matrilysin, Matrin, Matrix metalloproteinase 7, MMP 7, MMP7, MPSL1, PUMP 1, Pump 1 protease, PUMP1, Uterine metalloproteinase
Background

Matrix metalloproteinase-7 (MMP-7)/ matrilysin is a member of the MMP family, but is structurally different from the other MMPs by virtue of the absence of a conserved COOH-terminal protein domain. MMPs are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and cancer metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. MMP-7 degrades proteoglycans, fibronectin, elastin and casein, and is involved in wound healing, tumor progression, pulmonary fibrosis, and development of choroidal neovascularization in age-related macular degeneration. The expression of MMP-7 is increased in most tumors. The gene encoding MMP-7 is part of a cluster of MMP genes which localize to chromosome 11q22.3.


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