MPV17 Antibody 7 Publications

Rabbit Polyclonal| Catalog number: 10310-1-AP

Featured Product KD/KO validated

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Con: 20 μg/150 μl

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Species specificity:
human, mouse

Positive WB detected in:
mouse kidney tissue, human brain tissue, human heart tissue, human liver tissue, human placenta tissue

Positive IHC detected in:
human pancreas cancer tissue

Positive IF detected in:
HeLa cells

Recommended dilution:
WB : 1:500-1:1000
IHC : 1:20-1:200
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
MpV17 mitochondrial inner membrane protein

Calculated molecular weight:
20 kDa

Observed molecular weight:
20kd

GenBank accession number:

Gene ID (NCBI):

Gene symbol
MPV17

Synonyms
MPV17, Protein Mpv17, SYM1
Background

MPV17, also termed as SYM1, encodes an inner mitochondrial membrane protein. It’s potential candidate that may account for the mitochondrial (mt) DNA depletion syndromes (MDDS) characterized by a severe, tissue-specific decrease of mtDNA copy number and ultimate organ failure. It’s a human ortholog of the mouse kidney disease gene Mpv17. Absence or malfunction of MPV17 causes oxidative phosphorylation (OXPHOS) failure and mtDNA depletion, not only in affected individuals but also in Mpv17-/- mice. MPV17 contribute to ROS homeostasis, but the downstream signaling is unknown yet. Catalog# 10310-1-AP is a rabbit polyclonal antibody raised against the full-length of human MPV17.


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