MYH7-specific Antibody 7 Publications

Rabbit Polyclonal| Catalog number: 22280-1-AP

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Freight/Packing

Con: 99 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
mouse heart tissue

Positive IP detected in:
mouse heart tissue

Positive IHC detected in:
mouse heart tissue, human skeletal muscle tissue

Positive IF detected in:
mouse heart tissue

Recommended dilution:
WB : 1:600-1:2000
IP : 0.5-4.0 ug for IP and 1:200-1:1000 for WB
IHC : 1:20-1:200
IF : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Immunogen:
Peptide

Full name:
myosin, heavy chain 7, cardiac muscle, beta

Calculated molecular weight:
223 kDa

Observed molecular weight:
200-220 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
MYH7

Synonyms
beta MHC, CMD1S, CMH1, MPD1, MYH7, MyHC beta, MyHC slow, MYHCB, Myosin 7, Myosin heavy chain 7, SPMD, SPMM
Background

Myosin is the major contractile protein of all eukaryotic cells, existing as a hexameric molecule composed of two myosin heavy chains (MHCs) that contain the catalytic sites for ATP hydrolysis, and four lower molecular weight myosin light chains. MYH7 encodes the slow/beta-cardiac myosin heavy chain (MHC), which is the major MHC isoform of cardiac ventricles. It is also expressed in slow, oxidative, type 1 muscle fibers of skeletal muscle. Numerous mutations of MYH7 have been linked to familial hypertrophic cardiomyopathy. This antibody can specifically recognize endogenous MYH7, not cross-reacting with other MHCs. (2523412, 14520662)


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