Glucocorticoid receptor Antibody 8 Publications

Rabbit Polyclonal| Catalog number: 24050-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 64 μg/150 μl

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Species specificity:
human, mouse, rat, Rare minnows

Positive WB detected in:
HeLa cells, C2C12 cells

Positive IP detected in:
mouse heart tissue

Positive IF detected in:
HepG2 cells

Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IF : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)

Calculated molecular weight:
86 kDa

Observed molecular weight:
94-97 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
NR3C1

Synonyms
GCCR, GCR, Glucocorticoid receptor, GR, GRL, NR3C1
Background

NR3C1 is a receptor for glucocorticoids, which owns a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE) and as a modulator of other transcription factors. It is involved in cell proliferation and differentiation and specifically implicated in newborn birth weight, thus providing a biological mechanism by which NR3C1 expression may influence birth weight [PMID:22810058]. It also act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth [PMID:15037546]. This antibody is specific to NR3C1.


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