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  • KD/KO Validated

OMA1 Polyclonal antibody

OMA1 Polyclonal Antibody for IHC, WB,ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, IHC,ELISA

Conjugate

Unconjugated

Cat no : 17116-1-AP

Synonyms

2010001O09Rik, DAB1, MPRP 1, MPRP1, OMA1, YKR087C, ZMPOMA1



Tested Applications

Positive WB detected inmouse liver tissue, K-562 cells
Positive IHC detected inhuman liver tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0

Recommended dilution

ApplicationDilution
Western Blot (WB)WB : 1:500-1:1000
Immunohistochemistry (IHC)IHC : 1:50-1:500
Sample-dependent, check data in validation data gallery

Product Information

17116-1-AP targets OMA1 in WB, IHC,ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Cited Reactivity human, mouse
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen OMA1 fusion protein Ag10803
Full Name OMA1 homolog, zinc metallopeptidase (S. cerevisiae)
Calculated molecular weight 524 aa, 60 kDa
Observed molecular weight 60 kDa
GenBank accession numberBC012915
Gene symbol OMA1
Gene ID (NCBI) 115209
Conjugate Unconjugated
Form Liquid
Purification Method Antigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

OMA1 (Overlapping with the m-AAA protease 1 homolog) is also named as MPRP1 (Metalloprotease-related protein 1) and belongs to the peptidase M48 family. It is a zinc metalloprotease that spans the inner mitochondrial membrane with a number of predicted membrane spanning domains and the 60 kDa form of OMA1 rapidly accumulated concomitantly with the cleavage of all OPA1 variants, the 40 kDa form of OMA1 may be the mature form (M-OMA1), and the 35 kDa is a cleaved form (S-OMA1), with the 60 kDa form being the active enzyme (PMID:20334834, 30518622). This antibody is speicific to OMA1.

Protocols

Product Specific Protocols
WB protocol for OMA1 antibody 17116-1-APDownload protocol
IHC protocol for OMA1 antibody 17116-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols

Publications

SpeciesApplicationTitle
humanWB

Mol Cell

Reciprocal Roles of Tom7 and OMA1 during Mitochondrial Import and Activation of PINK1.

Authors - Shiori Sekine
  • KO Validated
humanWB

Cell Death Dis

Nitric oxide triggers the assembly of "type II" stress granules linked to decreased cell viability.

Authors - Anaïs Aulas
mouseWB

Sci Adv

Adult-onset obesity is triggered by impaired mitochondrial gene expression.

Authors - Kara L Perks
humanWB

J Cell Physiol

Laminar Shear Stress Promotes Mitochondrial Homeostasis in Endothelial Cells.

Authors - Li-Hong Wu
mouseWB

Int J Mol Sci

Mitochondrial Optic Atrophy (OPA) 1 Processing Is Altered in Response to Neonatal Hypoxic-Ischemic Brain Injury.

Authors - Ana A Baburamani
humanWB

J Cancer

Niclosamide inhibits ovarian carcinoma growth by interrupting cellular bioenergetics.

Authors - Fugen Shangguan