P16-INK4A Antibody 37 Publications

Rabbit Polyclonal| Catalog number: 10883-1-AP

Featured Product KD/KO validated

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Con: 55 μg/150 μl

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Species specificity:
human, monkey, mouse, rat

Positive WB detected in:
HEK-293 cells, HEK293 cells , HeLa cells, PC-3 cells

Positive IP detected in:
HEK-293 cells

Positive IHC detected in:
human cervical cancer tissue, human cervical cancer tissue, human lung cancer tissue, human lymphoma tissue, human pancreas tissue, human tonsillitis tissue

Positive IF detected in:
SH-SY5Y cells, HeLa cells

Positive FC detected in:
HeLa cells

Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:500-1:2000 for WB
IHC : 1:50-1:500
IF : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)

Calculated molecular weight:
11 kDa

Observed molecular weight:
16-18 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
CDKN2A

Synonyms
ARF, ARF,CDKN2A, CDK4 inhibitor p16 INK4, CDK4 inhibitor p16INK4, CDK4I, CDKN2, CDKN2A, CMM2, INK4, INK4a, MLM, MTS 1, MTS1, Multiple tumor suppressor 1, p14, p14ARF, P16, p16 INK4, p16 INK4a, p16INK4, p16INK4a, TP16
Background

CDKN2A generates several transcript variants which differ in their first exons. At least three alternatively-spliced variants encoding distinct proteins have been reported, and two are related, named p16-INK4 and p14 respectively, sharing 50% identity. The third one is completely structurally un-related, called p14(ARF) or p19(ARF). 10883-1-AP reacted with p16 specifically. P16 plays an important role in regulating the cell cycle, and mutations in p16 increase the risk of developing a variety of cancers, notably melanoma.


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