• All
  • Primary Antibodies
  • Conjugated Antibodies for IF
  • Conjugated Antibodies for FC
  • Secondary Antibodies
  • Antibody Labeling KitsNew
  • ELISA Kits
  • IHC Kits
  • Magnetic Cell Separation Kits
  • Cytokines & Growth Factors
  • Neutralizing/activating Antibodies
  • Nanobody-based Reagents
  • Accessory Products and Kits
  • Fusion Proteins
×
×
Host
0
Species Reactivity
0
Species Reactivity
0
Conjugate
0
Conjugate
0
Compatible Species
0
Conjugate
0
  • Featured Product
  • KD/KO Validated

PCSK5 Polyclonal antibody

PCSK5 Polyclonal Antibody for IHC, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse and More (1)

Applications

IHC, ELISA

Conjugate

Unconjugated

Cat no : 16470-1-AP

Synonyms

hPC6, PC5, PC6, PC6A, PCSK5, Proprotein convertase 5, Proprotein convertase 6, SPC6

Validation Data Gallery

Filter:
  • Immunohistochemistry (IHC) staining of human kidney tissue using PCSK5 Polyclonal antibody (16470-1-AP)

    IHC staining of human kidney using 16470-1-AP

    Immunohistochemical analysis of paraffin-embedded human kidney tissue slide using 16470-1-AP (PCSK5 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

  • Immunohistochemistry (IHC) staining of human kidney tissue using PCSK5 Polyclonal antibody (16470-1-AP)

    IHC staining of human kidney using 16470-1-AP

    Immunohistochemical analysis of paraffin-embedded human kidney tissue slide using 16470-1-AP (PCSK5 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

  • Immunohistochemistry (IHC) staining of mouse brain tissue using PCSK5 Polyclonal antibody (16470-1-AP)

    IHC staining of mouse brain using 16470-1-AP

    Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using 16470-1-AP (PCSK5 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

  • Immunohistochemistry (IHC) staining of mouse brain tissue using PCSK5 Polyclonal antibody (16470-1-AP)

    IHC staining of mouse brain using 16470-1-AP

    Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using 16470-1-AP (PCSK5 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

  • Immunohistochemistry (IHC) staining of human brain tissue using PCSK5 Polyclonal antibody (16470-1-AP)

    IHC staining of human brain using 16470-1-AP

    Immunohistochemical analysis of paraffin-embedded human brain using 16470-1-AP (PC6 antibody) at dilution of 1:50 (under 10x lens).

  • Immunohistochemistry (IHC) staining of human spleen tissue using PCSK5 Polyclonal antibody (16470-1-AP)

    IHC staining of human spleen using 16470-1-AP

    Immunohistochemical analysis of paraffin-embedded human spleen using 16470-1-AP (PC6 antibody) at dilution of 1:200 (under 10x lens).

  • Immunohistochemistry (IHC) staining of human spleen tissue using PCSK5 Polyclonal antibody (16470-1-AP)

    IHC staining of human spleen using 16470-1-AP

    Immunohistochemical analysis of paraffin-embedded human spleen using 16470-1-AP (PC6 antibody) at dilution of 1:200 (under 40x lens).

  • Immunohistochemistry (IHC) staining of human skin tissue using PCSK5 Polyclonal antibody (16470-1-AP)

    IHC staining of human skin using 16470-1-AP

    Immunohistochemical analysis of paraffin-embedded human skin using 16470-1-AP (PC6 antibody) at dilution of 1:100 (under 10x lens).

  • Immunohistochemistry (IHC) staining of human skin tissue using PCSK5 Polyclonal antibody (16470-1-AP)

    IHC staining of human skin using 16470-1-AP

    Immunohistochemical analysis of paraffin-embedded human skin using 16470-1-AP (PC6 antibody) at dilution of 1:100 (under 40x lens).

  • Immunohistochemistry (IHC) staining of human heart tissue using PCSK5 Polyclonal antibody (16470-1-AP)

    IHC staining of human heart using 16470-1-AP

    Immunohistochemical analysis of paraffin-embedded human heart using 16470-1-AP (PC6 antibody) at dilution of 1:200 (under 10x lens).

  • Immunohistochemistry (IHC) staining of human heart tissue using PCSK5 Polyclonal antibody (16470-1-AP)

    IHC staining of human heart using 16470-1-AP

    Immunohistochemical analysis of paraffin-embedded human heart using 16470-1-AP (PC6 antibody) at dilution of 1:200 (under 40x lens).

  • Immunohistochemistry (IHC) staining of human testis tissue using PCSK5 Polyclonal antibody (16470-1-AP)

    IHC staining of human testis using 16470-1-AP

    Immunohistochemical analysis of paraffin-embedded human testis using 16470-1-AP (PC6 antibody) at dilution of 1:200 (under 10x lens).

  • Immunohistochemistry (IHC) staining of human testis tissue using PCSK5 Polyclonal antibody (16470-1-AP)

    IHC staining of human testis using 16470-1-AP

    Immunohistochemical analysis of paraffin-embedded human testis using 16470-1-AP (PC6 antibody) at dilution of 1:200 (under 40x lens).

  • Immunohistochemistry (IHC) staining of human brain tissue using PCSK5 Polyclonal antibody (16470-1-AP)

    IHC staining of human brain using 16470-1-AP

    Immunohistochemical analysis of paraffin-embedded human brain using 16470-1-AP (PC6 antibody) at dilution of 1:50 (under 40x lens).

Tested Applications

Positive IHC detected inhuman kidney tissue, human brain tissue, human skin tissue, human heart tissue, human testis tissue, human spleen tissue, mouse brain tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0

Recommended dilution

ApplicationDilution
Immunohistochemistry (IHC)IHC : 1:50-1:500
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Published Applications

KD/KOSee 1 publications below

Product Information

16470-1-AP targets PCSK5 in IHC, ELISA applications and shows reactivity with human, mouse samples.

Tested Reactivity human, mouse
Cited Reactivityhuman, rat
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen PCSK5 fusion protein Ag9552
Full Name proprotein convertase subtilisin/kexin type 5
Calculated Molecular Weight 102 kDa, 207 kDa
Observed Molecular Weight 210 kDa
GenBank Accession NumberBC012064
Gene Symbol PCSK5
Gene ID (NCBI) 5125
RRIDAB_2283381
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.

Background Information

PC5 ,a mammalian kex2-like processing endoprotease, mediates posttranslational endoproteolytic processing for several integrin alpha subunits.It has been identified in rat and mouse endocrine and neuroendocrine tissues,and is encoded by multiple mRNAs that generate two splice variant isoforms referred to as PC5A (102KDa) and PC5B (207KDa) .PC5A is smaller than PC5B and it can be processed into two forms (117 kDa and 65 kDa) in neuronal cells(PMID:11457520).

Protocols

Product Specific Protocols
IHC protocol for PCSK5 antibody 16470-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols

Publications

SpeciesApplicationTitle
rat

Mol Med Rep

MicroRNA‑338‑3p regulates age‑associated osteoporosis via targeting PCSK5.

Authors - Jie Tong
  • KD Validated
View Article
human

Biochem Biophys Rep

Secreted factors from adipose tissue-derived mesenchymal stem cells suppress oxygen/glucose deprivation-induced cardiomyocyte cell death via furin/PCSK-like enzyme activity.

Authors - Yuki Tachida
View Article