PKC gamma Antibody 0 Publications

Mouse Monoclonal| Catalog number: 66429-1-Ig |CloneNo.: 2F4B9

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Con: 150 μg/150 μl

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Species specificity:
human, mouse, rat, pig

Positive WB detected in:
HeLa cells

Positive IHC detected in:
human brain tissue

Positive IF detected in:
SH-SY5Y cells

Recommended dilution:
WB : 1:2000-1:5000
IHC : 1:50-1:500
IF : 1:50-1:500

Product Information


Source:
Mouse

Purification method:
Protein A purification

Isotype:
IgG2a

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
protein kinase C, gamma

Calculated molecular weight:
78 kDa

Observed molecular weight:
78 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
PRKCG

Synonyms
PKC gamma, PKCC, PKCG, PRKCG, Protein kinase C gamma type, protein kinase C, gamma, SCA14
Background

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC gamma is a neuron-specific member of the classical PKCs and is activated and translocated to subcellular regions as a result of various stimuli, including diacylglycerol synthesis, increased intracellular Ca(2+) and phorbol esters. Defects in this protein have been associated with spinocerebellar ataxia type 14 (SCA14), an autosomal dominant neurodegenerative disease.


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