Plakoglobin/gamma catenin Antibody 0 Publications

Mouse Monoclonal| Catalog number: 66445-1-Ig |CloneNo.: 1A5D10

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Freight/Packing

Con: 150 μg/150 μl

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Species specificity:
human, rat

Positive WB detected in:
human heart tissue, rat heart tissue

Positive IHC detected in:
human breast cancer tissue, human breast cancer tissue, human skin tissue

Recommended dilution:
WB : 1:1000-1:4000
IHC : 1:50-1:500

Product Information


Source:
Mouse

Purification method:
Protein G purification

Isotype:
IgG1

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
junction plakoglobin

Calculated molecular weight:
82 kDa

Observed molecular weight:
82 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
JUP

Synonyms
ARVD12, Catenin gamma, CTNNG, Desmoplakin 3, Desmoplakin III, DP3, DPIII, junction plakoglobin, JUP, PDGB, PKGB, γ-Catenin
Background

Plakoglobin (γ-catenin), a member of the Armadillo proteins, plays important roles in cell adhesion with α-catenin and β-catenin, is involved in Wnt signaling, and is translocated into the nucleus and binds LEF1. Plakoglobin is a major cytoplasmic component of both desmosomes and adherens junctions, and is the only known constituent common to submembranous plaques in both of these structures, which are located at the intercalated disc (ICD) of cardiomyocytes. Plakoglobin links cadherins to the actin cytoskeleton. Mutations in plakoglobin are associated with arrhythmogenic right ventricular dysplasia and Pemphigus vulgaris.


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