RBBP6 Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 11882-1-AP

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Freight/Packing

Con: 37 μg/150 μl

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Species specificity:
human, mouse

Positive WB detected in:
HEK-293 cells, Transfected HEK-293 cells

Positive IF detected in:
HeLa cells

Recommended dilution:
WB : 1:500-1:1000
IF : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
retinoblastoma binding protein 6

Calculated molecular weight:
1792aa,200 kDa

Observed molecular weight:
200 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
RBBP6

Synonyms
DKFZp686P0638, DKFZp761B2423, MY038, P2P R, P2PR, PACT, Protein P2P R, RBBP6, RBQ 1, RBQ1, SNAMA
Background

RBBP6 (retinoblastoma binding protein 6) is a multifunctional protein that interacts with both p53 and pRb and has been implicated in mRNA processing. It has also been identified as a putative E3 ubiquitin ligase due to the presence of a RING finger domain [PMID:18851979]. RBBP6 contains an N-terminal ubiquitin-like domain and a cysteine-rich RING finger-like domain, through which it promotes the ubiquitination of p53 by Hdm2 in an E4-like manner [PMID:17470788]. It is implicated in a diverse set of cellular functions, including mRNA metabolism, regulation of the cell cycle, tumorigenesis, and development [PMID:12938151,17470788].


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