RRM2 Antibody 1 Publications

Rabbit Polyclonal| Catalog number: 11661-1-AP

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Freight/Packing

Con: 37 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
K-562 cells, A431 cells, HeLa cells, K-562 cells

Positive IP detected in:
K-562 cells

Positive IHC detected in:
human tonsillitis tissue

Recommended dilution:
WB : 1:500-1:1000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
ribonucleotide reductase M2 polypeptide

Calculated molecular weight:
389aa,45 kDa

Observed molecular weight:
45kd

GenBank accession number:

Gene ID (NCBI):

Gene symbol
RRM2

Synonyms
R2, RR2, RR2M, RRM2
Background

Ribonucleotide reductase M2 subunit is one of two subunits that constitute ribonucleotide reductase, the enzyme that catalyzes the conversion of ribonucleotide 5'-diphosphates into 2'-deoxyribonucleotides, a rate-limiting step in the production of 2'-deoxyribonucleoside 5'-diphosphates (dNTP) required for DNA synthesis and repair that is required for DNA synthesis and repair [PMID:20825972, 19250552]. RRM2 is only expressed during the late G1/early S phase, and degraded in late S phase, and the activity of RNR, and therefore DNA synthesis and cell proliferation, is controlled during the cell cycle by the synthesis and degradation of RRM2 subunit [PMID:3894352].


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