SCN9A/Nav1.7-Specific Antibody 2 Publications

Rabbit Polyclonal| Catalog number: 20257-1-AP

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Con: 42 μg/150 μl

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Species specificity:
human, rat

Positive WB detected in:
A431 cells

Positive IHC detected in:
human brain tissue

Positive IF detected in:
PC-12 cells

Recommended dilution:
WB : 1:500-1:2000
IHC : 1:20-1:200
IF : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Immunogen:
Peptide

Full name:
sodium channel, voltage-gated, type IX, alpha subunit

Calculated molecular weight:
226 kDa

Observed molecular weight:
228 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
SCN9A

Synonyms
ETHA, hNE Na, Nav1.7, NE NA, NENA, Neuroendocrine sodium channel, Peripheral sodium channel 1, PN1, SCN9A
Background

SCN9A, also named as NENA, PN1, ETHA, NE-NA, Nav1.7 and hNE-Na, belongs to the sodium channel family. SCN9A mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, SCN9A forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-sensitive Na+ channel isoform. SCN9a plays a role in pain mechanisms, especially in the development of inflammatory pain. Defects in SCN9A are the cause of primary erythermalgia or autosomal recessive congenital indifference to pain or paroxysmal extreme pain disorder (PEPD). The antibody is specific to SCN9A


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