Sestrin 2 Antibody 4 Publications

Rabbit Polyclonal| Catalog number: 21346-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 34 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
mouse thymus tissue, HeLa cells, K-562 cells, mouse lung tissue, NIH/3T3 cells

Positive IF detected in:
Hela cells

Recommended dilution:
WB : 1:1000-1:4000
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
sestrin 2

Calculated molecular weight:
480aa,54 kDa

Observed molecular weight:
60-66 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
SESN2

Synonyms
DKFZp761M0212, DKFZp761M02121, HI95, SES2, SESN2, SEST2, Sestrin 2, Sestrin2
Background

Sestrins, including sestrin-1 (PA26), sestrin-2 (Hi95), and sestrin-3, are 48 to 65 kDa cystein sulfinyl reductases and they modulate peroxide signaling and antioxidant defense. These proteins selectively reduce or repair hyperoxidized forms of typical 2-Cys peroxiredoxins within eukaryotes. Expression of these proteins is regulated by p53, a tumor suppressor protein. Sestrin 2 is implicated in the regulation of cell growth and survival, in cellular responses to different stress conditions, and also acts as a positive regulator of autophagy. Sestrin 2 is approximately a 57.6kDa protein (480 amino acids).


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