SORLA Antibody 1 Publications

Rabbit Polyclonal| Catalog number: 22592-1-AP

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Con: 33 μg/150 μl

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Species specificity:
human, mouse, rat

Positive IP detected in:
mouse brain tissue

Positive IHC detected in:
human brain tissue, human brain tissue, rat brain tissue

Recommended dilution:
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen Affinity purified

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
sortilin-related receptor, L(DLR class) A repeats-containing

Calculated molecular weight:
2214aa,248 kDa

Observed molecular weight:
300 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
SORL1

Synonyms
LR11, LRP9, SORL1, SORLA, SorLA 1, Sortilin related receptor
Background

SorLA also known as SorL1 or LR11, is a multiligand receptor belonging to the LDL receptor superfamily. It is also a member of vacuolar protein sorting-10 (Vps10) family and is enriched in the brain. SorLA acts as an sorting receptor for APP and prevents amyloidogenic processing of APP. Downregulation of SorLA has been found in patients with sporadic Alzheimer disease (AD). Currently SorLA has emerged as a potential target for AD therapy. (25404298)


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