TLR6 Antibody 1 Publications

Rabbit Polyclonal| Catalog number: 22240-1-AP

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Freight/Packing

Con: 54 μg/150 μl

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Species specificity:
human, mouse

Positive WB detected in:
RAW 264.7 cells, RAW264.7 cells

Recommended dilution:
WB : 1:500-1:2000

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
toll-like receptor 6

Calculated molecular weight:
480aa,56 kDa

Observed molecular weight:
95-110 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
TLR6

Synonyms
CD286, TLR6, toll like receptor 6
Background

TLR6, also known as CD286, belongs to the Toll-like receptor (TLR) family which are important in the innate immune response to pathogens. TLRs are highly conserved from Drosophila to human and share structural and functional similarities. TLR6 can form a heterodimer with TLR2. TLR6 and TLR2 both are recruited to the macrophage phagosome, where they recognize peptidoglycan, a Gram-positive pathogen component (PMID: 11095740). TLR6 interacts with CD36, following CD36 stimulation by oxLDL or amyloid-beta 42, and forms a heterodimer with TLR4. The trimeric complex is internalized and triggers inflammatory response.


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