TPH1 Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 20879-1-AP

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Freight/Packing

Con: 49 μg/150 μl

Choose size:

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Species specificity:
human, mouse

Positive WB detected in:
SH-SY5Y cells

Recommended dilution:
WB : 1:200-1:1000

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
tryptophan hydroxylase 1

Calculated molecular weight:
466aa,53 kDa

Observed molecular weight:
51 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
TPH1

Synonyms
TPH, TPH1, TPRH, TRPH, Tryptophan 5 hydroxylase 1, Tryptophan 5 monooxygenase 1, tryptophan hydroxylase 1
Background

Tryptophan hydroxylase 1(TPH1) catalyzes the rate-limiting step in the synthesis of serotonin in the periphery. Recently, it has been shown that expression of the tryptophan hydroxylase 1 gene is increased in lungs and pulmonary endothelial cells from patients with idiopathic pulmonary arterial hypertension. It catalyzes the biopterin-dependent monooxygenation of tryptophan to 5-hydroxytryptophan (5HT), which is subsequently decarboxylated to form the neurotransmitter serotonin. The protein has low expression.


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