TPTE Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 12982-1-AP

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Freight/Packing

Con: 32 μg/150 μl

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Species specificity:
human

Positive WB detected in:
HepG2 cells, BxPC-3 cells, HEK-293 cells, HepG2 cells, human testis tissue

Positive IHC detected in:
human testis tissue

Positive IF detected in:
BxPC-3 cells

Recommended dilution:
WB : 1:500-1:2000
IHC : 1:20-1:200
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
transmembrane phosphatase with tensin homology

Calculated molecular weight:
62 kDa;64 kDa

Observed molecular weight:
62kd,64kd

GenBank accession number:

Gene ID (NCBI):

Gene symbol
TPTE

Synonyms
Cancer/testis antigen 44, CT44, PTEN2, TPTE, Tumor antigen BJ HCC 5
Background

TPTE(Transmembrane phosphatase with tensin homology) is also named as CT44, BJ-HCC-5 and belongs to the non receptor class of the protein-tyrosine phosphatase family. The gene encodes a predicted polypeptide of 551 amino acids with at least 2 potential transmembrane domains and a tyrosine phosphatase motif. TPTE may be involved in the signal transduction pathways of the endocrine or spermatogenic function of the testis(PMID:10598804). It is putatively involved in linking the cell membrane to cytoskeleton. This protein is very similar in sequence to PTEN through the phosphatase and C2 domains, but lacks a PDZ binding motif and an extensively phosphorylated C-terminal tail(PMID:17240336). It has 4 isoforms produced by alternative splicing.


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