Zyxin Antibody 0 Publications

Mouse Monoclonal| Catalog number: 60254-1-Ig |CloneNo.: 4D7E7

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Freight/Packing

Con: 150 μg/150 μl

Choose size:

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Species specificity:
human, mouse

Positive WB detected in:
HeLa cells, A431 cells, MCF-7 cells

Positive IHC detected in:
human kidney tissue, human breast cancer tissue, human cervical cancer tissue, human kidney tissue, human placenta tissue, human testis tissue

Positive IF detected in:
HeLa cells

Recommended dilution:
WB : 1:500-1:2000
IHC : 1:20-1:200
IF : 1:20-1:200

Product Information


Source:
Mouse

Purification method:
Protein G purification

Isotype:
IgG1

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
zyxin

Calculated molecular weight:
80 kDa

Observed molecular weight:
78kd

GenBank accession number:

Gene ID (NCBI):

Gene symbol
ZYX

Synonyms
ESP 2, HED 2, ZYX, zyxin, Zyxin 2
Background

Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin (ZYX) is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles.


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