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- KD/KO Validated
p38 MAPK Antibody
p38 MAPK Monoclonal Antibody for IHC, WB, ELISA
Cat no : 66234-1-Ig
CSAID binding protein, CSBP, CSBP1, CSBP2, CSPB1, EXIP, MAP kinase 14, MAP kinase MXI2, MAP kinase p38 alpha, MAPK 14, MAPK14, MAX interacting protein 2, Mxi2, p38, p38 MAPK, p38ALPHA, PRKM14, PRKM15, RK, SAPK2A
|Positive WB detected in||HeLa cells, HEK-293 cells, pig heart tissue, human heart tissue, Jurkat cells, MCF-7 cells, HSC-T6 cells|
|Positive IHC detected in||human lung cancer tissue, human gliomas tissue|
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
|Western Blot (WB)||WB : 1:2000-1:6000|
|Immunohistochemistry (IHC)||IHC : 1:250-1:1000|
|Sample-dependent, check data in validation data gallery|
66234-1-Ig targets p38 MAPK in WB, IHC, ELISA applications and shows reactivity with human, pig samples.
|Tested Reactivity||human, pig|
|Cited Reactivity||human, mouse, piglet|
|Host / Isotype||Mouse / IgG2b|
|Immunogen||p38 MAPK fusion protein Ag5797|
|Full Name||mitogen-activated protein kinase 14|
|Calculated molecular weight||360aa,41 kDa|
|Observed molecular weight||38-42 kDa|
|GenBank accession number||BC031574|
|Gene ID (NCBI)||1432|
|Purification Method||Protein A purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.|
MAPK14(mitogen-activated protein kinase 14) is also named as SAPK2A, p38MAPK, CSBP1, RK, p38, EXIP, Mxi2, CSBP2, PRKM14, PRKM15, CSPB1, p38ALPHA and belongs to the MAP kinase subfamily. MAPK14-signaling is a central pathway for the integration of instructive signals in dendritic cells for T(H)17 differentiation and inflammation(PMID:22231518). It plays an important role in the regulation of hematopoietic stem cellself-renewal in vitro and inhibition of MAPK14 activation with a small molecule inhibitor may represent a novel approach to promote ex vivo expansion of hematopoietic stem cell(PMID:21198398). This protein has 4 isoforms produced by alternative splicing.
Cathepsin C promotes microglia M1 polarization and aggravates neuroinflammation via activation of Ca2+-dependent PKC/p38MAPK/NF-κB pathway.
Effects of RhoC downregulation on the angiogenesis characteristics of myeloma vascular endothelial cells.
Melamine causes testicular toxicity by destroying blood-testis barrier in piglets.
Free Radic Biol Med
Cathelicidin-WA attenuates LPS-induced inflammation and redox imbalance through activation of AMPK signaling.
Mol Med Rep
Mda‑7/IL‑24 induces the differentiation of B cell lymphoma via activation of the P38 mitogen activated protein kinase signaling pathway.