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  • HEK293 expressed
  • Endotoxin-free
  • Animal-component free

Animal-free Recombinant Human Thrombin (Coagulation Factor II)



Species Reactivity




Cat no : HZ-3010


Coagulation factor II, F2, Prothrombin, PT, Thrombin

Technical Specifications

GeneID 2147
Species human
Expression HEK293
Activity N/A
Purity >95%
Molecular Mass 36 kDa, glycosylated
Formulation 20 mM MES pH 6.0 + 500 mM Choline Chloride, See Certificate of Analysis for details
Species Reactivity human

Stability and Reconstitution

Stability and Storage This protein is stable for 1 year from the date of receipt ifstored between (-20°C) and (-80°C). Repeated freeze thaw cycles should be avoided.

Product Description

Animal-free Recombinant Human Thrombin is expressed in human 293 cells as a monomeric glycoprotein with an apparent molecular mass of 36 kDa. Production in human 293 cells ensures authentic glycosylation. Thrombin is a coagulation protein and a serine protease that catalyzes numerous coagulation correlated reactions. Thrombin also regulates the behavior of additional cells through protease activated receptors and endorses platelet activation. This recombinant protein is produced in a human cell expression system with serum-free, chemically defined media.


Coagulation factors are a group of related proteins that are essential for normal blood clotting (haemostasis). After an injury, clots protect the body by sealing off damaged blood vessels and preventing further blood loss. Prothrombin circulates in the bloodstream in an inactive form until an injury occurs. In response to that, prothrombin is converted to its active form, thrombin. Thrombin next converts a protein called fibrinogen into fibrin. Thrombin is also important for cell growth and division, tissue repair, and new blood vessels formation - angiogenesis (PMID: 11154146; 16549895; 15892853; 12421139).


Coagulation factor II, F2, Prothrombin, PT, Thrombin



Clin Ther

A review of three stand-alone topical thrombins for surgical hemostasis.

Authors - Christine MCheng