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A review of three stand-alone topical thrombins for surgical hemostasis.
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Animal-free Recombinant Human Thrombin is expressed in human 293 cells as a monomeric glycoprotein with an apparent molecular mass of 36 kDa. Production in human 293 cells ensures authentic glycosylation. Thrombin is a coagulation protein and a serine protease that catalyzes numerous coagulation correlated reactions. Thrombin also regulates the behavior of additional cells through protease activated receptors and endorses platelet activation. This recombinant protein is produced in a human cell expression system with serum-free, chemically defined media.
Coagulation factors are a group of related proteins that are essential for normal blood clotting (haemostasis). After an injury, clots protect the body by sealing off damaged blood vessels and preventing further blood loss. Prothrombin circulates in the bloodstream in an inactive form until an injury occurs. In response to that, prothrombin is converted to its active form, thrombin. Thrombin next converts a protein called fibrinogen into fibrin. Thrombin is also important for cell growth and division, tissue repair, and new blood vessels formation - angiogenesis (PMID: 11154146; 16549895; 15892853; 12421139).