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Recombinant Human ASGR2 protein (rFc Tag)

Species

Human

Purity

>90 %, SDS-PAGE

Tag

rFc Tag

Activity

not tested

Cat no : Eg3052

Validation Data Gallery

  • Purity of Recombinant Human ASGR2 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) conditions and stained using Coomassie blue.

    Purity of Recombinant Human ASGR2 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) conditions and stained using Coomassie blue.

Product Information

Purity >90 %, SDS-PAGE
Endotoxin <0.1 EU/μg protein, LAL method
Activity 
Not tested
Expression HEK293-derived Human ASGR2 protein Gln80-Ala311 (Accession# P07307-1) with a rabbit IgG Fc tag at the C-terminus.
GeneID 433
Accession P07307-1
PredictedSize 52.4 kDa
SDS-PAGE 58-68 kDa, reducing (R) conditions
Formulation Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
Reconstitution Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
Storage Conditions
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

Background

ASGR2, or asialoglycoprotein receptor 2, is a gene that plays a significant role in the clearance of glycoproteins from the bloodstream. The receptor is highly expressed in the liver, where it is located on the sinusoidal face of hepatocytes, and is also found in other cell types such as peritoneal macrophages, intestinal epithelial cells, and testis. The serum ASGR2 level is an efficacy biomarker for balloon pulmonary angioplasty in patients with chronic thromboembolic pulmonary hypertension. Gastric cancer cell-invasive activity was significantly decreased with the knockdown of ASGR2, forced expression of ASGR2 promoted invasive activity.

References:

1. Xu WJ. et al. (2024). Front Immunol. 15:1402250.
2. Tanaka H. et al. (2018). Mol Cancer Res. 16(9):1420-1429.