ASNA1 Antibody 0 Publications

Mouse Monoclonal| Catalog number: 66346-1-Ig |CloneNo.: 1B7C11

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Freight/Packing

Con: 150 μg/150 μl

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Species specificity:
human, rat, pig, mouse

Positive WB detected in:
rat brain tissue, fetal human brain tissue, HEK-293 cells, Neuro-2a cells, pig brain tissue

Positive IHC detected in:
human lung cancer tissue

Positive IF detected in:
HEK-293 cells

Recommended dilution:
WB : 1:500-1:2000
IHC : 1:50-1:500
IF : 1:50-1:500

Product Information


Source:
Mouse

Purification method:
Protein G purification

Isotype:
IgG1

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
arsA arsenite transporter, ATP-binding, homolog 1 (bacterial)

Calculated molecular weight:
38.7 kDa

Observed molecular weight:
37-41 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
ASNA1

Synonyms
ARSA, ARSA I, ARSA1, Arsenical pump driving ATPase, Arsenite stimulated ATPase, ASNA1, ATPase ASNA1, hARSA I, hASNA I, TRC40
Background

ASNA1 (also known as TRC40) is a highly conserved ATPase involved in efflux of arsenite and antimonite. Reduced ASNA1 expression is associated with significant inhibition of cell growth, increased apoptosis and increased sensitivity to cisplatin and arsenite.Thus ASNA1 is proposed to be a target to overcome resistance to cancer chemotherapy. In addition, ASNA1 has been identified as an ER targeting factor for tail-anchored proteins in the posttranslational membrane insertion pathway.


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