Published Applications
| WB | See 6 publications below |
Product Information
21950-1-AP targets ATM in WB, ELISA applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Cited Reactivity | human, mouse, pig |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen |
CatNo: Ag15123 Product name: Recombinant human ATM protein Source: e coli.-derived, PKG Tag: GST Domain: 1332-1479 aa of BC007023 Sequence: IDHLFISNLPEIVVELLMTLHEPANSSASQSTDLCDFSGDLDPAPNPPHFPSHVVKATFAYISNCHKTKLKSILEILSKSPDSYQKILLAICEQAAETNNVYKKHRILKIYHLFVSLLLKDIKSGLGGAWAFVLRDVIYTLIHYINQR Predict reactive species |
| Full Name | ataxia telangiectasia mutated |
| Calculated Molecular Weight | 3056 aa, 351 kDa |
| GenBank Accession Number | BC007023 |
| Gene Symbol | ATM |
| Gene ID (NCBI) | 472 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | Q13315 |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA. |
Background Information
The ATM protein is a member of the phosphatidylinositol 3-kinase family of proteins that respond to DNA damage by phosphorylating key substrates involved in DNA repair and/or cell cycle control. It is involved in mitogenic signal transduction, meiotic recombination, detection of DNA damage, and cell cycle control.
Publications
| Species | Application | Title |
|---|---|---|
Toxicol Appl Pharmacol Polychlorinated biphenyl quinone induces oxidative DNA damage and repair responses: The activations of NHEJ, BER and NER via ATM-p53 signaling axis. | ||
Tumour Biol Ataxia-telangiectasia group D complementing gene (ATDC) upregulates matrix metalloproteinase 9 (MMP-9) to promote lung cancer cell invasion by activating ERK and JNK pathways. | ||
Phytomedicine Toosendanin-induced liver damage through irreparable DNA damage and autophagy flow blockade | ||
PLoS Pathog SIRT5-mediated desuccinylation of the porcine deltacoronavirus M protein drives pexophagy to enhance viral proliferation | ||
Mol Oncol Olaparib synergy screen reveals Exemestane induces replication stress in triple-negative breast cancer |
