Ataxin 2 Antibody 2 Publications

Rabbit Polyclonal| Catalog number: 21776-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 37 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
Jurkat cells, DU 145 cells, HEK-293 cells, HeLa cells

Positive IP detected in:
HEK-293 cells

Positive IHC detected in:
human gliomas tissue

Positive IF detected in:
HepG2 cells, HEK-293 cells

Recommended dilution:
WB : 1:1000-1:4000
IP : 0.5-4.0 ug for IP and 1:500-1:2000 for WB
IHC : 1:20-1:200
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
ataxin 2

Calculated molecular weight:
1313aa,140 kDa

Observed molecular weight:
140-150 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
ATXN2

Synonyms
ataxin 2, ATX2, ATXN2, FLJ46772, SCA2, TNRC13
Background

ATXN2 contains a repeat structure with 22 or 23 triplets coding for glutamine and the (CAG)8CAA(CAG)4CAA(CAG)8 sequence; expansion of this domain to a size ≥34 triplets with a pure CAG sequence primarily causes autosomal dominant SCA2 [PMID:18418684], while ATXN2 expansions with CAA interruptions were observed as the cause of Levo-dopa responsive Parkinson’s disease [PMID:10668726]. ATXN2 expansions associated with ALS were reported to be interrupted by at least one CAA triplet [PMID:21537950].


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