BAX Antibody 274 Publications

Rabbit Polyclonal| Catalog number: 50599-2-Ig

Featured Product KD/KO validated

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Freight/Packing

Con: 51 μg/150 μl

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Species specificity:
human, mouse, rat, guinea pig, rabbit, sheep

Positive WB detected in:
RAW 264.7 cells,Raji cells, rat kidney tissue, mouse kidney tissue, COLO 320 cells, HeLa cells , HEK-293 cells, rat lung tissue

Positive IP detected in:
Raji cells

Positive IHC detected in:
human lymphoma tissue,human gliomas tissue, human breast cancer tissue, mouse brain tissue, human liver cancer tissue, human testis tissue

Positive IF detected in:
HEK-293 cells,HeLa cells

Positive FC detected in:
Raji cells, HeLa cells

Recommended dilution:
WB : 1:2000-1:12000
IP : 0.5-4.0 ug for IP and 1:1000-1:4000 for WB
IHC : 1:20-1:200
IF : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Protein A purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
BCL2-associated X protein

Calculated molecular weight:
21 kDa

Observed molecular weight:
21-24 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
BAX

Synonyms
Apoptosis regulator BAX, BAX
Background

BAX, also named as BCL2L4, is a pro-apoptotic member of the Bcl-2 protein family, which plays a pivotal role in controlling cell life and death. Bax largely localizes to the cytoplasm of healthy cells, but accumulates on the outer mitochondrial membrane upon apoptosis induction (PMID: 9108035). BAX can commit a cell to apoptosis by translocation from the cytosol to the mitochondria and permeabilization of the outer mitochondrial membrane, which leads to the release of cytochrome c from mitochondria (PMID: 21763611). The expression of BAX is upregulated by the tumor suppressor protein p53, and BAX has been shown to be involved in p53-mediated apoptosis (PMID: 8183579).


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