ADPRM Polyclonal antibody

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  WB analysis using 17017-1-AP

  Various lysates were subjected to SDS PAGE followed by western blot with 17017-1-AP (C17orf48 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours.

ADPRM Polyclonal Antibody for WB, ELISA

Cat No. 17017-1-AP

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat, pig

Applications

WB, ELISA

Synonyms

C17orf48, ADPRibase Mn, ADPRibase-Mn, ADP-Ribose/CDP-Alcohol Diphosphatase, Manganese Dependent, CDP choline phosphohydrolase

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Tested Applications

• Positive WB detected in: mouse brain tissue, rat brain tissue, pig brain tissue

Recommended dilution

• Western Blot (WB): WB : 1:1000-1:4000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, Check data in validation data gallery.

Product Information

17017-1-AP targets ADPRM in WB, ELISA applications and shows reactivity with human, mouse, rat, pig samples.

• Tested Reactivity: human, mouse, rat, pig
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen: ADPRM fusion protein Ag9997
• Full Name: chromosome 17 open reading frame 48
• Calculated Molecular Weight: 40 kDa
• Observed Molecular Weight: 45 kDa
• GenBank Accession Number: BC001294
• Gene Symbol: C17orf48
• Gene ID (NCBI): 56985
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• UNIPROT ID: Q3LIE5
• Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.
• Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage. 20ul sizes contain 0.1% BSA.

Background Information

ADPRM (ADP-ribose/CDP-alcohol diphosphatase, manganese dependent) is a manganese-dependent glycophosphatase primarily responsible for the breakdown of molecules such as ADP-ribose, IDP-ribose, CDP-glycerol, CDP-choline and CDP-ethanolamine in the cell. The protein is predicted to be located in the cytoplasm and possesses 2',3'-cyclic nucleotide 2'-phosphodiesterase activity, manganese ion-binding activity, and pyrophosphatase activity. ADPRM plays an important role in embryonic development, particularly in the formation of the heart and lungs. In addition, ADPRM may be involved in immune cell signaling, acting as a second messenger for ADP-ribose to activate TRPM2, which in turn regulates oxidative/nitrosative stress.