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CAMKK2 Antibody 6 Publications

Rabbit Polyclonal| Catalog number: 11549-1-AP

Featured Product KD/KO validated

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Con: 23 μg/150 μl

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Tested Applications

Applications:
WB, IHC, IF, ELISA
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Images See all

CAMKK2 Antibody WB PC-3 cells 11549-1-AP

PC-3 cells were subjected to SDS PAGE followed by western blot with 11549-1-AP(CAMKK2 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours

CAMKK2 Antibody IHC human prostate cancer tissue 11549-1-AP

Immunohistochemistry of paraffin-embedded human prostate cancer tissue slide using 11549-1-AP( CAMKK2 Antibody) at dilution of 1:200 (under 10x lens).

CAMKK2 Antibody IHC human prostate cancer tissue 11549-1-AP

Immunohistochemistry of paraffin-embedded human prostate cancer tissue slide using 11549-1-AP( CAMKK2 Antibody) at dilution of 1:200 (under 40x lens).

CAMKK2 Antibody IF PC-3 cells 11549-1-AP

Immunofluorescent analysis of PC-3 cells using 11549-1-AP(CAMKK2 antibody) at dilution of 1:25 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IgG(H+L)

Species specificity:
human, mouse, rat
Positive WB detected in:
PC-3 cells, fetal human brain tissue, HeLa cells, human brain tissue, human heart tissue, Jurkat cells
Positive IHC detected in:
human prostate cancer tissue

Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
Positive IF detected in:
PC-3 cells
Recommended dilution:
WB : 1:500-1:1000
IHC : 1:100-1:400
IF : 1:10-1:100

Protocols

Product-specific protocols

Standard Protocols

Product Information

Source:
Rabbit
Purification method:
Antigen affinity purification
Isotype:
IgG
Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information

Immunogen:
CAMKK2 fusion protein Ag2093
Full name:
calcium/calmodulin-dependent protein kinase kinase 2, beta
Calculated molecular weight:
588aa,60 kDa
Observed molecular weight:
55-60 kDa
GenBank accession number:
BC026060
Gene ID (NCBI):
10645
Gene symbol
CAMKK2
Synonyms
CaM kinase kinase 2, CaM kinase kinase beta, CaM KK 2, CaM KK beta, CAMKK, CaMKK 2, CaMKK beta, CAMKK2, CAMKKB, KIAA0787

Background

CAMKK2(calcium/calmodulin-dependent protein kinase kinase 2) is also named as CAMKKB, KIAA0787 and belongs to the protein kinase superfamily. It regulates hypothalamic production of the orexigenic hormone NPY and contributes to the regulation of energy balance. CAMKK2 in vivo reduces tumor growth suggests that reactivation of CAMKK2 by development of new drugs may be a new strategy to prolong the period to respond androgen-deprivation therapy(ADT)(PMID:22549914). It can be autophosphorylated(PMID:19369195). It has 7 isoforms produced by alternative splicing.


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