Caspase 1 Antibody 6 Publications

Rabbit Polyclonal| Catalog number: 22915-1-AP

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Freight/Packing

Con: 53 μg/150 μl

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Species specificity:
human, mouse, rat, cow

Positive WB detected in:
Jurkat cells, C6 cells, HeLa cells, MCF-7 cells, MDA-MB-453s cells, NIH/3T3 cells, Raji cells

Positive IHC detected in:
human spleen tissue

Positive IF detected in:
C6 cells

Recommended dilution:
WB : 1:500-1:2000
IHC : 1:100-1:400
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Antigen Affinity purified

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)

Calculated molecular weight:
404aa,45 kDa

Observed molecular weight:
45-47 kDa,30 kDa,35 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
CASP1

Synonyms
CASP 1, CASP1, Caspase 1, Caspase 1/p20/p10, Caspase1, ICE, IL 1 beta converting enzyme, IL 1BC, IL1BC, IL1BCE, Interleukin 1 beta convertase, p10, p20, P45
Background

CASP1(caspase-1) is also named as IL1BC, IL1BCE and belongs to the peptidase C14A family. It is a cysteine protease that regulates inflammatory processes through its capacity to process and activate the interleukin-1-beta (IL1B), IL18, and IL33 precursor proteins. The active caspase-1 can increase cellular membrane permeability and intracellular calcium levels, which facilitates lysosome exocytosis and release of host antimicrobial factors and microbial products(PMID:21804020). It has 5 isoforms produced by alternative splicing. 22915-1-AP can recognize all the five isoforms of caspase 1. It also can recognize p45 procaspase and the mature fragments p10 and p20..


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