|Positive WB detected in||NIH/3T3 cells, A549 cells, HeLa cells|
|Positive IP detected in||A549 cells|
|Positive IHC detected in||human lung cancer tissue, human heart tissue, human liver tissue, human lung tissue|
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
|Western Blot (WB)||WB : 1:600-1:5000|
|Immunoprecipitation (IP)||IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB|
|Immunohistochemistry (IHC)||IHC : 1:50-1:500|
|Sample-dependent, check data in validation data gallery|
The immunogen of 16447-1-AP is Caveolin-1 Fusion Protein expressed in E. coli.
|Tested Reactivity||human, mouse, rat|
|Cited Reactivity||human, mouse, rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Caveolin-1 fusion protein Ag8049|
|Full Name||caveolin 1, caveolae protein, 22kDa|
|Calculated molecular weight||22 kDa|
|Observed molecular weight||20-25 kDa|
|GenBank accession number||BC006432|
|Gene ID (NCBI)||857|
|Purification Method||Antigen affinity purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.|
Caveolin-1 (CAV1), a multifunctional protein, is the main constituent molecule of caveolae and represents a scaffolding molecule for several signaling molecules including epidermal growth factor receptor (PMID: 19641024). Several studies have implicated that a reduced expression of CAV1 was found in cancers including head and neck carcinoma (PMID: 19002186). However, other studies recognize CAV1 as a tumor promoter because CAV1 is overexpressed in various kinds of cancers, especially in oral cancer (PMID: 20558341). Recent study also show that CAV1 is involved in astric Cancer (PMID: 25339030). MW of Caveolin-1 is from 20-25 kDa due to phosphorylation (PMID: 10198051).
Am J Physiol Lung Cell Mol Physiol
Identification of CAV1 and DCN as potential predictive biomarkers for lung adenocarcinoma.
Am J Chin Med
Puerarin Reduces Blood Pressure in Spontaneously Hypertensive Rats by Targeting eNOS.
Betulinic acid suppresses breast cancer aerobic glycolysis via caveolin-1/NF-κB/c-Myc pathway.
Tumoral microvesicle-activated glycometabolic reprogramming in fibroblasts promotes the progression of oral squamous cell carcinoma.
Am J Respir Crit Care Med
Distinct Cancer-Promoting Stromal Gene Expression Depending on Lung Function.
POH1 contributes to hyperactivation of TGF-β signaling and facilitates hepatocellular carcinoma metastasis through deubiquitinating TGF-β receptors and caveolin-1.