Cdc37 Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 10218-1-AP

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Freight/Packing

Con: 30 μg/150 μl

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Species specificity:
human, mouse, rat, monkey

Positive WB detected in:
HEK-293 cells, A431 cells, COS-7 cells, HEK-293 cells, Jurkat cells

Positive IP detected in:
HEK-293 cells

Positive IHC detected in:
human colon cancer tissue

Positive IF detected in:
HeLa cells, A431 cells, HEK-293 cells, MCF-7 cells

Positive FC detected in:
MCF-7 cells

Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:500-1:2000 for WB
IHC : 1:20-1:200
IF : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
cell division cycle 37 homolog (S. cerevisiae)

Calculated molecular weight:
44 kDa

Observed molecular weight:
45-50 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
CDC37

Synonyms
CDC37, CDC37A, Hsp90 co chaperone Cdc37, P50CDC37
Background

Cdc (cell division control) family of proteins are regulatory proteins involved in the processes of cell cycle and proliferation. Cdc37, migrated as a protein of 50 kDa in SDS PAGE, is a co-chaperone protein that recruits several immature client kinases to Hsp90 for proper folding. It functions in association with Hsp90, although little is known of its mechanism of action or where it fits into a folding pathway involving other Hsp90 cochaperones. Cdc37 up-regulation is a common early event in some localized human cancers. But, the effect of Cdc37 dysregulation in human cells is unclear.


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