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  • KD/KO Validated

TORC1/CRTC1 Polyclonal antibody

TORC1/CRTC1 Polyclonal Antibody for IHC, IP, WB, ELISA

Host / Isotype

Rabbit / IgG


human, mouse and More (1)





Cat no : 10441-1-AP


CRTC1, KIAA0616, MECT1, TORC 1, TORC1, TORC1/CRTC1, Transducer of CREB protein 1, WAMTP1

Tested Applications

Positive WB detected inmouse kidney tissue, A431 cells, Jurkat cells, L02 cells, mouse brain tissue
Positive IP detected inmouse kidney tissue
Positive IHC detected inhuman colon cancer tissue, mouse brain tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0

Recommended dilution

Western Blot (WB)WB : 1:500-1:1000
Immunoprecipitation (IP)IP : 0.5-4.0 ug for 1.0-3.0 mg of total protein lysate
Immunohistochemistry (IHC)IHC : 1:50-1:500
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

10441-1-AP targets TORC1/CRTC1 in WB, IP, IHC, IF, ELISA applications and shows reactivity with human, mouse samples.

Tested Reactivity human, mouse
Cited Reactivityhuman, mouse, rat
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen TORC1/CRTC1 fusion protein Ag0693
Full Name CREB regulated transcription coactivator 1
Calculated Molecular Weight 75 kDa
Observed Molecular Weight68 kDa
GenBank Accession NumberBC028050
Gene Symbol CRTC1
Gene ID (NCBI) 23373
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.

Background Information

CRTC1, also named as MECT1,TORC1, and WAMTP1, belongs to the TORC family. It is a transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. CRTC1 acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. It enhances the interaction of CREB1 with TAF4. CRTC1 regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. It is a potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. CRTC1 is also a coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). In the hippocampus, CRTC1 involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. It may be required for dendritic growth of developing cortical neurons. This is a rabbit polyclonal antibody raised against residues near N terminus of human CRTC1. CRTC1 has some isoforms produced by alternative splicing with MW of 67 kDa, 68 kDa and 62 kDa. Sometimes it appears as a 75-80 kDa band probably due to phosphorylation (PMID: 17183642; 22770221)


Product Specific Protocols
WB protocol for TORC1/CRTC1 antibody 10441-1-APDownload protocol
IHC protocol for TORC1/CRTC1 antibody 10441-1-APDownload protocol
IP protocol for TORC1/CRTC1 antibody 10441-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols



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