Validation Data Gallery
|Sample-dependent, check data in validation data gallery|
The immunogen of 23936-1-AP is CTGF Fusion Protein expressed in E. coli.
|Tested Reactivity||human, mouse|
|Cited Reactivity||human, mouse, rat, canine, pig, sheep|
|Host / Isotype||Rabbit / IgG|
|Immunogen||CTGF fusion protein Ag21008|
|Full Name||connective tissue growth factor|
|Calculated molecular weight||349 aa, 38 kDa|
|Observed molecular weight||38 kDa|
|GenBank accession number||BC087839|
|Gene ID (NCBI)||1490|
|Purification Method||Antigen affinity purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.|
CTGF, also known as CCN2 or connective tissue growth factor, is a member of the CCN family of matricellular proteins. CTGF, a cysteine-rich, matrix-associated, heparin-binding protein, is widely expressed in various human tissues and organs. CTGF has important roles in many biological processes, including cell adhesion, migration, proliferation, angiogenesis, skeletal development, and tissue wound repair, and is critically involved in fibrotic disease and several forms of cancers. In western blotting, there are three different forms of CTGF reported: monomeric forms at approximately 36-38 kDa, homodimeric forms at approximately 70 kDa, and lower molecular mass fragment forms.
Exp Cell Res
CTGF regulates cyclic stretch-induced vascular smooth muscle cell proliferation via microRNA-19b-3p.
Citrus alkaline extracts prevent fibroblast senescence to ameliorate pulmonary fibrosis via activation of COX-2.
Myricetin Suppresses the Propagation of Hepatocellular Carcinoma via Down-Regulating Expression of YAP.
SRT1720 retards renal fibrosis via inhibition of HIF1α /GLUT1 in diabetic nephropathy.
Aspirin targets P4HA2 through inhibiting NF-κB and LMCD1-AS1/let-7g to inhibit tumour growth and collagen deposition in hepatocellular carcinoma.
Induction of Fibrosis and Autophagy in Kidney Cells by Vinyl Chloride.