Cathepsin B Antibody 6 Publications

Rabbit Polyclonal| Catalog number: 12216-1-AP

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Freight/Packing

Con: 49 μg/150 μl

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Species specificity:
human, mouse, frog, rat

Positive WB detected in:
A375 cells, HT-1080 cells, human brain tissue, human liver tissue, mouse brain tissue, NIH/3T3 cells

Positive IHC detected in:
human ovary tumor tissue, human breast cancer tissue, human colon cancer tissue, human ovary tumor tissue

Positive IF detected in:
A375 cells

Positive FC detected in:
MCF-7 cells

Recommended dilution:
WB : 1:500-1:1000
IHC : 1:100-1:400
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
cathepsin B

Calculated molecular weight:
229aa,38 kDa

Observed molecular weight:
38 kDa, 44 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
CTSB

Synonyms
APP secretase, APPS, cathepsin B, Cathepsin B1, CPSB, CTSB
Background

CTSB(Cathepsin B) is also named as CPSB and belongs to the peptidase C1 family. It participates in intracellular degradation and turnover of proteins. Cathepsin B precursors found in human malignant ascites fluid do not possess mannose-rich carbohydrates suggesting that a defect in the post translational processing of carbohydrate moieties on tumor. Cathepsin B exists as both glycosylated and unglycosylated forms(PMID:1637335). In rat macrophages and hepatocytes pro- cathepsin B is 39 kDa (unglycosylated =35 kDa), whereas in human fibroblasts procathepsin B is 44.5-46kDa (unglycosylated=39kDa)(PMID:2097084). It can be detected the 43 kDa form of pro-CTSB, 31 kDa and 25 kDa marure forms in mouse brain by western blot(PMID:20616152).


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