DDR1/CD167a Recombinant monoclonal antibody, PBS Only

• 

  WB analysis using 84438-6-RR (same clone as 84438-6-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 84438-6-RR (DDR1 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84438-6-PBS in a different storage buffer formulation.

• 

  IHC staining of mouse brain using 84438-6-RR (same clone as 84438-6-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using 84438-6-RR (DDR1 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 84438-6-PBS in a different storage buffer formulation.

DDR1/CD167a Uni-rAb^® Recombinant Antibody for WB, IHC, Indirect ELISA

Cat No. 84438-6-PBS

Clone No.241796D10

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, IHC, Indirect ELISA

Synonyms

DDR1, 241796D10, CAK, CD167, CD167 antigen-like family member A

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Product Information

84438-6-PBS targets DDR1/CD167a in WB, IHC, Indirect ELISA applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen:

  CatNo: Eg1675

  Product name: Recombinant Human DDR1 protein (rFc Tag)

  Source: mammalian cells-derived, pHZ-KIsec-C-rFc

  Tag: C-rFc

  Domain: 21-416 aa of NM_001297654

  Sequence: DMKGHFDPAKCRYALGMQDRTIPDSDISASSSWSDSTAARHSRLESSDGDGAWCPAGSVFPKEEEYLQVDLQRLHLVALVGTQGRHAGGLGKEFSRSYRLRYSRDGRRWMGWKDRWGQEVISGNEDPEGVVLKDLGPPMVARLVRFYPRADRVMSVCLRVELYGCLWRDGLLSYTAPVGQTMYLSEAVYLNDSTYDGHTVGGLQYGGLGQLADGVVGLDDFRKSQELRVWPGYDYVGWSNHSFSSGYVEMEFEFDRLRAFQAMQVHCNNMHTLGARLPGGVECRFRRGPAMAWEGEPMRHNLGGNLGDPRARAVSVPLGGRVARFLQCRFLFAGPWLLFSEISFISDVVNNSSPALGGTFPPAPWWPPGPPPTNFSSLELEPRGQQPVAKAEGSPT

• Full Name: discoidin domain receptor tyrosine kinase 1
• Calculated Molecular Weight: 101 kDa
• Observed Molecular Weight: 120 kDa
• GenBank Accession Number: NM_001297654
• Gene Symbol: DDR1
• Gene ID (NCBI): 780
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purfication
• UNIPROT ID: Q08345-1
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

DDR1, or Discoidin Domain Receptor 1, is a member of the receptor tyrosine kinase (RTK) family, which plays a significant role in various cellular processes including cell proliferation, adhesion, migration, and extracellular matrix (ECM) remodeling. DDR1 is known for its unique discoidin domain that allows it to bind specifically to certain collagens, initiating downstream signaling pathways that can lead to cell transformation and tumor progression. Abnormal activation of DDR1 is closely associated with the development of various solid tumors, and it has been shown that DDR1 can prevent immune cells from infiltrating triple-negative breast cancer (TNBC) and eliminate tumor cells.