DLK1 Antibody 9 Publications

Rabbit Polyclonal| Catalog number: 10636-1-AP

Featured Product KD/KO validated

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Con: 51 μg/150 μl

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Species specificity:
human, mouse, rat, pig

Positive WB detected in:
mouse placenta tissue, A549 cells, MCF-7 cells, mouse brain tissue, mouse ovary tissue

Positive IHC detected in:
human breast cancer tissue

Recommended dilution:
WB : 1:500-1:1000
IHC : 1:50-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
delta-like 1 homolog (Drosophila)

Calculated molecular weight:
41 kDa

Observed molecular weight:
45-60 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
DLK1

Synonyms
DLK, DLK 1, DLK1, FA1, pG2, Pref 1, PREF1, Protein delta homolog 1, ZOG
Background

DLK1, also named PREF1, FA1, or pG2, is a transmembrane protein belonging to the epidermal growth factor (EGF)-like superfamily (PMID: 8095043). It contains six EGF-like repeats in the extracellular region. DLK1 is abundant in preadipocytes and regulate adipocyte differentiation negatively (PMID: 8500166). Deficiency of DLK1 gives rise to growth retardation and accelerated adiposity in mouse model. Expression of DLK1 is found in tumors with neuroendocrine features that implies DLK1 may be involved in neuroendocrine differentiation (PMID: 8095043). It has been reported overexpression of DLK1 could lead to the development of metabolic abnormalities by impairment of adipocyte function in mice (PMID: 12588883). The gene of DLK1 maps to chromosome 14q32, and encodes a 383-amino acid protein with a calculated molecular mass of 41 kDa. In preadipocytes, multiple discrete forms of DLK1 protein of 45-60 kDa are present, owing in part to N-linked glycosylation (PMID: 8500166).


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