FLCN Antibody 2 Publications

Rabbit Polyclonal| Catalog number: 11236-2-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 47 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
mouse thymus tissue, A549 cells, HeLa cells, mouse kidney tissue

Positive IP detected in:
HeLa cells

Positive IHC detected in:
human ovary tumor tissue

Recommended dilution:
WB : 1:200-1:1000
IP : 0.5-4.0 ug for IP and 1:200-1:1000 for WB
IHC : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
folliculin

Calculated molecular weight:
38 kDa

Observed molecular weight:
38-45 kDa,64 kDa,20-26 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
FLCN

Synonyms
BHD, DKFZp547A118, FLCL, FLCN, FLJ45004, FLJ99377, folliculin
Background

FLCN, also named as BHD, belongs to the folliculin family. It may play a role in the pathogenesis of an uncommon form of kidney cancer through its association with an inherited disorder of the hair follicle (fibrofolliculomas). FLCN may be a tumor suppressor. It is involved in colorectal tumorigenesis. It may be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. Mutation of FLCN may cause the BHD(Birt-Hogg-Dube syndrome ) or (PSP) primary spontaneous pneumothorax. And it may be involved in renal cell carcinoma. This antibody can recognize all the 3 isoforms of FLCN (38-45 kDa,64 kDa,20-26 kDa).


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