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  • KD/KO Validated

FLCN Polyclonal antibody

FLCN Polyclonal Antibody for WB, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, IP, IHC, ELISA

Conjugate

Unconjugated

Cat no : 11236-2-AP

Synonyms

BHD, FLCL, FLCN, folliculin



Tested Applications

Positive WB detected inA431 cells, HeLa cells, HEK-293 cells, NCCIT cells

Recommended dilution

ApplicationDilution
Western Blot (WB)WB : 1:500-1:1000
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

11236-2-AP targets FLCN in WB, IP, IHC, ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Cited Reactivityhuman, mouse, rat
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen FLCN fusion protein Ag1746
Full Name folliculin
Calculated Molecular Weight 38 kDa
Observed Molecular Weight64-75 kDa
GenBank Accession NumberBC015687
Gene Symbol FLCN
Gene ID (NCBI) 201163
RRIDAB_2103285
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.

Background Information

FLCN, also named as BHD, belongs to the folliculin family. It may play a role in the pathogenesis of an uncommon form of kidney cancer through its association with an inherited disorder of the hair follicle (fibrofolliculomas). FLCN may be a tumor suppressor. It is involved in colorectal tumorigenesis. It may be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. Mutation of FLCN may cause the BHD(Birt-Hogg-Dube syndrome ) or (PSP) primary spontaneous pneumothorax. And it may be involved in renal cell carcinoma.

Protocols

Product Specific Protocols
WB protocol for FLCN antibody 11236-2-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols

Publications

SpeciesApplicationTitle
mouseWB,IP

FASEB J

AMPK promotes induction of the tumor suppressor FLCN through activation of TFEB independently of mTOR.

Authors - Caterina Collodet
mouseWB

DNA Repair (Amst)

Activation of AMP-activated protein kinase by MAPO1 and FLCN induces apoptosis triggered by alkylated base mismatch in DNA.

Authors - Lim Teik How TH
  • KD Validated
humanIHC

Front Mol Biosci

FLCN Regulates HIF2α Nuclear Import and Proliferation of Clear Cell Renal Cell Carcinoma.

Authors - Xuyang Zhao
WB

J Trace Elem Med Biol

Methionine-chelated Zn promotes anabolism by integrating mTOR signal and autophagy pathway in juvenile yellow catfish.

Authors - Kun Wu
humanWB

Biochem Biophys Res Commun

Stabilization of MAPO1 by specific binding with folliculin and AMP-activated protein kinase in O?-methylguanine-induced apoptosis.

Authors - Sano Shiori S
  • KD Validated
ratWB

Curr Res Neurobiol

Propranolol reduces the accumulation of cytotoxic aggregates in C9orf72-ALS/FTD in vitro models

Authors - Mira Seidel