Filamin-C Polyclonal antibody, PBS Only

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  WB analysis of SGC-7901 using 28492-1-AP (same clone as 28492-1-PBS)

  SGC-7901 cells were subjected to SDS PAGE followed by western blot with 28492-1-AP (filamin-c antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 28492-1-PBS in a different storage buffer formulation.

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  IHC staining of human colon using 28492-1-AP (same clone as 28492-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human colon slide using 28492-1-AP (FLNC antibody) at dilution of 1:200 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 28492-1-PBS in a different storage buffer formulation.

Filamin-C Polyclonal Antibody for WB, IHC, Indirect ELISA

Cat No. 28492-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, IHC, Indirect ELISA

Synonyms

FLNC, FLN2, FilaminC, Filamin C, Filamin 2

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Product Information

28492-1-PBS targets Filamin-C in WB, IHC, Indirect ELISA applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen: Filamin-C fusion protein Ag29328
• Full Name: filamin C, gamma (actin binding protein 280)
• Calculated Molecular Weight: 291 kDa
• Observed Molecular Weight: 280-300 kDa
• GenBank Accession Number: NM_001458
• Gene Symbol: FLNC
• Gene ID (NCBI): 2318
• RRID: AB_2918171
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• UNIPROT ID: Q14315
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

Filamin C (FLNC; also known as γ-FLN; ABP-L; FLN2), a muscle-specific filamin and a large actin-cross-linking protein. Human filamins are ~280 kDa homodimers, each monomer consisting of an N-terminal actin-binding domain followed by 24 immunoglobulin (Ig)-like domains (d1 to d24), the last of which mediates dimerization. FLNC is specifically expressed in cardiomyocytes and skeletal myocytes and is involved in the maintenance of structural integrity. High filamin C associated with better prognosis of prostate cancer, leukemia and breast cancer patients. ( PMID: 25577646, PMID: 30867563, PMID: 31131323)