HMOX1 Antibody 57 Publications

Rabbit Polyclonal| Catalog number: 10701-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 59 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
mouse liver tissue, HeLa cells, HepG2 cells, HT-1080 cells, rat spleen tissue

Positive IP detected in:
HeLa cells

Positive IHC detected in:
human liver cancer tissue, human kidney tissue

Positive IF detected in:
HT-1080 cells

Recommended dilution:
WB : 1:500-1:1000
IP : 0.5-4.0 ug for IP and 1:500-1:2000 for WB
IHC : 1:100-1:400
IF : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
heme oxygenase (decycling) 1

Calculated molecular weight:
33 kDa

Observed molecular weight:
28-33 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
HMOX1

Synonyms
bK286B10, heme oxygenase (decycling) 1, Heme oxygenase 1, HMOX1, HO, HO 1, HO1, HSP32
Background

Heme oxygenase (HMOX1) catalyzes the first and rate-limiting step in the degradation of heme to yield equimolar quantities of biliverdin Ixa, carbon monoxide (CO), and iron. It has 3 isoforms: HO-1 is highly inducible, whereas HO-2 and HO-3 are constitutively expressed (PMID:10194478). Heme oxygenase-1 (HO-1) is expressed in many tissues and vascular smooth muscle cells, and endothelial cells (PMID:15451051) and has been identified as an important endogenous protective factor induced in many cell types by various stimulants, such as hemolysis, infiammatory cytokines,oxidative stress, heat shock, heavy metals, and endotoxin (PMID: 11522663). And the full-length HO-1 is very unstable and susceptible to truncation that generates an inactive, soluble form (28 kDa) (James R. Reed, Pharmacology, 535-568).


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