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Recombinant Human GP2 protein (rFc Tag)

Species

Human

Purity

>90 %, SDS-PAGE

Tag

rFc Tag

Activity

not tested

Cat no : Eg2446

Validation Data Gallery

Product Information

Purity >90 %, SDS-PAGE
Endotoxin <1.0 EU/μg protein, LAL method
Activity 
Not tested
Expression HEK293-derived Human GP2 protein Val29-Asn512 (Accession# P55259-1) with a rabbit IgG Fc tag at the C-terminus.
GeneID 2813
Accession P55259-1
PredictedSize 80.1 kDa
SDS-PAGE
Formulation Lyophilized from sterile PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
Reconstitution Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
Storage Conditions
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

Background

Pancreatic secretory granule membrane major glycoprotein (GP2) is the most abundant membrane component of zymogen granules secreted by pancreatic acinar cells. GP2 associates with the plasma membrane via glycosylphosphatidylinositol (GPI) linkage. It is released from the membrane of mature zymogen granules by an enzymatic mechanism. GP2 plays a role in defense against adhesive and invasive commensal bacteria during intestinal inflammation. GP2 is preferentially expressed in acinar cell carcinomas of the pancreas but the glycoprotein can rarely also be expressed in a variety of other tumor entities. The apparent molecular weight of GP2 is 70-100 kDa, which is larger than the calculated molecular weight, due to glycosylation.

References:

1. Scheele, G A et al. Pancreas vol. 9,2 (1994): 139-49.
2. Fukuoka, S et al. Proceedings of the National Academy of Sciences of the United States of America vol. 88,7 (1991): 2898-902. 
3. Kurashima, Yosuke et al. Nature communications vol. 12,1 1067. 16 Feb. 2021.
4. Uhlig, Ria et al. Pathology, research and practice vol. 238 (2022): 154123.