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Sample Type | Average | Range |
---|---|---|
Cell culture supernatant | 95% | 80%-103% |
Sample | n | mean ( pg/mL) | SD | CV% |
---|---|---|---|---|
1 | 20 | 2026.3 | 122.6 | 6.1 |
2 | 20 | 474.7 | 17.9 | 3.8 |
3 | 20 | 93.2 | 5.5 | 5.9 |
Sample | n | mean ( pg/mL) | SD | CV% |
---|---|---|---|---|
1 | 24 | 1899.2 | 148.5 | 7.8 |
2 | 24 | 453.3 | 28.0 | 6.2 |
3 | 24 | 87.7 | 7.8 | 8.9 |
Interleukin-12 (IL-12), is a cytokine that is secreted by activated phagocytes and dendritic cells and that induces interferon-γproduction by natural-killer and T lymphocytes. IL-12 is a 75 kDa heterodimer composed of a 35 kDa subunit (IL-12A p35) and a 40 kDa subunit (IL-12B p40) that is secreted by a wide variety of antigen presenting cells (APCs), including phagocytes, B cells and Langerhans cells. IL-12 p40 has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of IL-12 p40 was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of IL-12 p40 has been reported to be associated with the severity of atopic and non-atopic asthma in children.