|Positive IHC detected in||human liver cancer tissue, human lung cancer tissue, mouse liver tissue|
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
|Immunohistochemistry (IHC)||IHC : 1:50-1:500|
|Sample-dependent, check data in validation data gallery|
20215-1-AP targets IGF1B-Specific in IHC, IF,ELISA applications and shows reactivity with human samples.
|Cited Reactivity||chicken, human, mouse, rat|
|Host / Isotype||Rabbit / IgG|
|Full Name||insulin-like growth factor 1 (somatomedin C)|
|Calculated molecular weight||22 kDa|
|GenBank accession number||NM_001111285|
|Gene ID (NCBI)||3479|
|Purification Method||Antigen affinity purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.|
IGF1B, also named as IBP1, MGF, IGF-I and Somatomedin-C, belongs to the INS family. IGF1 is structurally and functionally related to INS but have a much higher growth-promoting activity. Altered expression or mutation of IGF-1 is associated with several human disorders, including type I diabetes and various forms of cancer. Defects in IGF1 are the cause of INS-like growth factor I deficiency (IGF1 deficiency) which is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation. The antibody is specific to isoform IGF-1B.
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