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IGF1B-Specific Polyclonal antibody

IGF1B-Specific Polyclonal Antibody for IHC,ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human and More (3)

Applications

IHC, IF,ELISA

Conjugate

Unconjugated

Cat no : 20215-1-AP

Synonyms

IBP1, IGF I, IGF1, IGF-1, IGF1A, IGF1B, IGFI, Insulin like growth factor I, Mechano growth factor, MGF, Somatomedin C



Tested Applications

Positive IHC detected inhuman liver cancer tissue, human lung cancer tissue, mouse liver tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0

Recommended dilution

ApplicationDilution
Immunohistochemistry (IHC)IHC : 1:50-1:500
Sample-dependent, check data in validation data gallery

Product Information

20215-1-AP targets IGF1B-Specific in IHC, IF,ELISA applications and shows reactivity with human samples.

Tested Reactivity human
Cited Reactivity chicken, human, mouse, rat
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen Peptide
Full Name insulin-like growth factor 1 (somatomedin C)
Calculated molecular weight 22 kDa
GenBank accession numberNM_001111285
Gene symbol IGF1
Gene ID (NCBI) 3479
Conjugate Unconjugated
Form Liquid
Purification Method Antigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

IGF1B, also named as IBP1, MGF, IGF-I and Somatomedin-C, belongs to the INS family. IGF1 is structurally and functionally related to INS but have a much higher growth-promoting activity. Altered expression or mutation of IGF-1 is associated with several human disorders, including type I diabetes and various forms of cancer. Defects in IGF1 are the cause of INS-like growth factor I deficiency (IGF1 deficiency) which is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation. The antibody is specific to isoform IGF-1B.

Protocols

Product Specific Protocols
IHC protocol for IGF1B-Specific antibody 20215-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols

Publications

SpeciesApplicationTitle

Chem Biol Interact

Oenothein B induced human non-small cell lung cancer A549 cell death by ROS-mediated PI3K/Akt/NF-κB signaling pathway.

Authors - Xiaodong Pei
mouseIF

Brain Res Bull

Systemic administration of scAAV9-IGF1 extends survival in SOD1G93AALS mice via inhibiting p38 MAPK and the JNK-mediated apoptosis pathway.

Authors - Wan Wang
chickenWB

Oxid Med Cell Longev

IGF1 Knockdown Hinders Myocardial Development through Energy Metabolism Dysfunction Caused by ROS-Dependent FOXO Activation in the Chicken Heart.

Authors - Yafan Gong
humanWB

Front Bioeng Biotechnol

Let-7i-5p Regulation of Cell Morphology and Migration Through Distinct Signaling Pathways in Normal and Pathogenic Urethral Fibroblasts.

Authors - Kaile Zhang
humanWB

Toxicol Res (Camb)

Clusterin increases mitochondrial respiratory chain complex I activity and protects against hexavalent chromium-induced cytotoxicity in L-02 hepatocytes.

Authors - Yuanyuan Xiao
mouseIHC

Evid Based Complement Alternat Med

Polysaccharides of Fructus corni Improve Ovarian Function in Mice with Aging-Associated Perimenopause Symptoms.

Authors - Yong Wang