NeutraKine® IL-23 p40 Monoclonal antibody
NeutraKine® IL-23 p40 Monoclonal Antibody for Neutralization,ELISA
Host / Isotype
Mouse / IgG1
Cat no : 69006-1-Ig
|Neutralization||Measured by its ability to neutralize IL-23 induced secretion of IL-17 by mouse splenocytes cultured invitro. The half neutralization dose (ND50) is typically 8-30 ng/mL in the presence of 4 ng/mL human IL-23.|
69006-1-Ig targets NeutraKine® IL-23 p40 in Neutralization,ELISA applications and shows reactivity with Human samples.
|Host / Isotype||Mouse / IgG1|
|Immunogen||human Humankine IL-23 p40 protein HZ-1254|
|Full Name||interleukin 23, alpha subunit p19|
|Gene ID (NCBI)||51561,3593|
|Purification Method||Protein G purification|
|Storage Buffer||Sterile PBS.|
|Reconstitution||This product was lyophilized from a 0.2 μm filtered solution in PBS. Reconstitute at 1.0 mg/mL in sterile H2O before use.|
|Stability and Storage||Lyophilized antibodies are stable for 1 year from the date of receipt if stored between (-20°C) and (-80°C). Upon reconstitution we recommend that the solution can be stored at (4°C) for short term or at (-20°C) to (-80°C) for long term. Repeated freeze thaw cycles should be avoided with reconstituted products.|
Interleukin 23 (IL-23) is a member of the IL12 cytokine family and composed of two subunits, IL12p40 and IL23p19. It is produced by antigen presenting cells and has been shown to promote the production and survival of a distinct lineage of T-cells called TH17 cells. A functional receptor for IL-23 (the IL-23 receptor) has been identified and is composed of IL-12Rβ1 and IL-23R. IL-23 is expressed chiefly by the macrophages and DCs. The IL-23R is found on memory T cells, NKT cells, macrophages, DCs, and naive T cells upon activation by TGF-βand IL-6. The main biological effects of IL-23 identified initially are stimulation of antigen presentation by DCs, T cell differentiation to Th17 cells, and production of interferon-γ (IFN-γ). IL-23 acts also as an end-stage effector cytokine through direct action on macrophages (PMID: 16393998;15657292;12023369;12610626).
This antibody is used to Block/Neutralize IL23 p40 protein.